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Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer

Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer

June 3, 2025 Category: Blog

Abstract Notch signaling is a conserved signaling pathway that participates in many aspects of mammary gland development and homeostasis, and has extensively been associated with breast tumorigenesis.Here, to unravel the as yet debated role of Notch3 in breast cancer development, we investigated its expression in human breast cancer samples and eff

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Destructive and nondestructive tests formulation for concrete containing polyolefin fibers

June 3, 2025 Category: Blog

Polyolefin fiber is a new type of fiber that was used in concrete to improve some of the poor properties of concrete including; tensile strength, ductility, and fracture energy.In this research, the contribution of Polyolefin fiber in improving the properties of hardened concrete was examined by adding polyolefin fibers to mix with different fiber

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Conditions for caribou persistence in the wolf-elk-caribou systems of the Canadian Rockies

June 3, 2025 Category: Blog

Woodland caribou populations are considered threatened in Alberta and have declined in the Canadian Rocky Mountain National Parks of Banff and Jasper despite protection from factors causing caribou populations to decline outside of parks.Recent research emphasizes the importance of the numeric response of wolves to moose in moose-caribou-wolf syste

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Grapevine scion gene expression is driven by rootstock and environment interaction

June 3, 2025 Category: Blog

Abstract Background Grafting is a horticultural practice used widely across woody perennial crop species to fuse together the root and shoot system of two distinct genotypes, the rootstock and the scion, combining beneficial traits from both.In grapevine, THERMAL XTC PEACH MANGO grafting is used in nearly 80% of all commercial vines to optimize fru

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Constitutively active microglial populations limit anorexia induced by the food contaminant deoxynivalenol

June 3, 2025 Category: Blog

Abstract Microglia are involved in neuroinflammatory processes during diverse pathophysiological conditions.To date, the possible contribution of these cells to deoxynivalenol (DON)-induced brain inflammation and anorexia has not yet been evaluated.DON, one of the most abundant trichothecenes found in cereals, has been implicated in mycotoxicosis i

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